Heiko Müller's paintings take their inspiration from such diverse sources as medieval icons, Dutch and Flemish Renaissance painting, folk art and contemporary comics. He gained first attention by combining medieval Christian icons with modern digital art. His latest work is close to the American lowbrow and pop surrealism movement. Characteristics of his paintings are animal illustrations with a very dark and apocalyptic mood, often appearing like modern takes on Bosch or Bruegel motifs. In his own words, he's "particularly thrilled by the kind of spiritual terror you find expressed in the paintings of the old Flemish masters, [...] trying to find out what happens when you apply that mood to the serene and harmless world of rural folk art."
Müller's most recent work marks a return to painting after a long period of drawing with coloured pencils, during which he developed special techniques to make the drawings appear like oil paintings. His preferred media are acrylic and oil on paper and oil on canvas, complemented by pencil drawings. Müller's art is exhibited and bought almost as often in the USA as in his native Europe.